I recommend choosing vet-approved, effective heartworm prevention chews that also protect against fleas, ticks, and internal worms. Look for palatable, easy-to-administer options tailored to your dog’s size, with proven safety records and consistent monthly dosing. Products like HEARTGARD®, NexGard Plus, and TRI-HEARTPLUS offer broad-spectrum coverage, making health routines simpler. If you think about, I’ll share detailed insights on these top chews and what to consider for your pup’s protection.

Key Takeaways

  • Choose vet-recommended, FDA-approved heartworm prevention chews with proven safety and effectiveness for your dog’s size and health.
  • Look for broad-spectrum formulas that protect against heartworms, fleas, ticks, and intestinal worms.
  • Select palatable, flavored chews to ensure consistent monthly administration and adherence.
  • Consider natural or chemical options based on your preferences, ensuring they meet safety standards.
  • Regular veterinary check-ups and proper dosing practices maximize long-term protection and health.

HEARTGARD® Plus Chewables for Dogs up to 25 lbs (Blue Box) 6-Month Supply

heartgard plus 6 month supply

If you’re looking for an easy, vet-recommended way to protect your small dog from heartworm disease, HEARTGARD® Plus Chewables for Dogs up to 25 lbs is an excellent choice. This blue box contains a six-month supply of delicious, real-beef flavored chewables that dogs love, making administration simple. It not only prevents heartworm but also treats and controls roundworms and hookworms, providing all-encompassing protection. Trusted by vets and used over 2.5 billion times, it’s a reliable, effective solution for small dogs. Just follow the instructions, guarantee your dog chews the entire dose, and enjoy peace of mind knowing your pet is protected.

Best For: small dog owners seeking a convenient, vet-recommended solution to protect their pets from heartworm, roundworms, and hookworms.

Pros:

  • Easy to administer with a tasty, real-beef flavor dogs love.
  • Provides comprehensive protection against multiple parasites.
  • Trusted by vets and used over 2.5 billion times, ensuring reliability.

Cons:

  • Must be given consistently every month for maximum effectiveness.
  • Only suitable for dogs weighing up to 25 lbs.
  • Requires proper storage to keep chewables protected from light.

Interceptor Plus Heartworm & Worm Prevention Chews for Dogs 8.1-25 lbs

https://m.media-amazon.com/images/I/51XYzK5JLjL._AC_SX679_.jpg

For dogs weighing between 8.1 and 25 pounds, Interceptor Plus Heartworm & Worm Prevention Chews offers a convenient, tasty solution to protect against multiple parasites. It prevents heartworm disease and treats adult hookworms, roundworms, whipworms, and tapeworms, covering common worms dogs encounter outdoors or in parks. These flavored chews are easy to give—just once a month, by hand or mixed with food. Each box contains six chews, providing a full six-month supply. Manufactured in the USA by Elanco, the product has high customer ratings and includes helpful calendar labels for easy dosing. It’s an effective, vet-recommended choice for all-encompassing parasite prevention.

Best For: dog owners seeking a palatable, comprehensive monthly parasite prevention solution for small dogs weighing 8.1-25 lbs.

Pros:

  • Provides broad-spectrum protection against heartworm, hookworms, roundworms, whipworms, and tapeworms.
  • Flavored with real chicken, making it easy and enjoyable for dogs to take.
  • Comes with calendar labels for simple monthly dosing reminders.

Cons:

  • Packaging issues have been reported, with some damage during shipping.
  • Limited to dogs weighing 8.1-25 lbs; not suitable for larger or smaller breeds.
  • Price may vary across vendors, and some may find it slightly more expensive than alternative options.

NexGard Plus Flea, Tick & Heartworm Preventive Chewables for Dogs

dog flea tick heartworm medication

NexGard Plus stands out as an excellent choice for dog owners seeking an extensive parasite prevention solution, especially for those with active pets weighing between 33.1 and 66 pounds. This soft, beef-flavored chew combines afoxolaner, moxidectin, and pyrantel to protect against fleas, ticks, and heartworm. It kills adult fleas, prevents five tick species, and effectively treats hookworms and roundworms, offering broad-spectrum coverage. Easy to administer once a month, many owners praise its palatability and convenience. Although it costs around $130 for three months, its effectiveness and all-encompassing protection make it a popular option for maintaining a healthy, parasite-free dog.

Best For: dog owners seeking comprehensive, month-long protection against fleas, ticks, and worms for active dogs weighing 33.1 to 66 pounds.

Pros:

  • Combines multiple active ingredients for broad-spectrum parasite prevention
  • Palatable, beef-flavored chewable easy to administer
  • Provides convenient, once-a-month protection for three months

Cons:

  • Relatively high cost at approximately $130 for a three-month supply
  • May not be suitable for dogs outside the specified weight range without proper dosing
  • Some owners may experience or observe minimal side effects or reactions

TRI-HEART PLUS Chewable Tablets for Dogs (6-Month Supply)

dog heart health supplement

TRI-HEART PLUS Chewable Tablets are an excellent choice for dog owners seeking reliable, long-term heartworm prevention, especially for small dogs weighing up to 25 pounds. These beef-flavored chewables come in a 6-month supply of six tablets, making it convenient and cost-effective. Manufactured in the USA by Merck, they effectively kill heartworm larvae and treat roundworms and hookworms. Administered monthly as directed by your vet, many dogs enjoy the taste and easily accept the medication. With positive reviews averaging 4.7 stars, owners trust TRI-HEART PLUS for its safety, effectiveness, and ease of use, keeping their dogs healthy year-round.

Best For: dog owners seeking a safe, effective, and convenient long-term heartworm prevention solution for small dogs weighing up to 25 pounds.

Pros:

  • Easy to administer and many dogs enjoy the beef flavor.
  • Provides 6 months of protection with a monthly dosing schedule.
  • Manufactured by Merck in the USA, ensuring quality and reliability.

Cons:

  • Only suitable for dogs up to 25 pounds; not appropriate for larger breeds.
  • Requires consistent monthly administration for maximum effectiveness.
  • May not be available at the lowest possible price without price matching or feedback.

PetArmor 7-Way De-Wormer for Dogs

dog de wormer medication

PetArmor 7-Way De-Wormer for Dogs is an excellent choice for small dog owners seeking a vet-quality, all-encompassing dewormer that’s easy to administer at home. It targets seven common worms, including tapeworms, roundworms, and hookworms, providing extensive protection for dogs weighing 6-25 lbs. The chewable tablets are flavored, making dosing simple—whether by hand, mixed with food, or treats. Designed for puppies 12 weeks and older, it’s safe and effective, with many owners reporting quick results. Regular use helps prevent parasite transmission and maintains your dog’s health without costly vet visits. It’s a practical, affordable solution for at-home parasite control.

Best For: small dog owners seeking a safe, effective, and easy-to-administer broad-spectrum dewormer for dogs weighing 6-25 lbs.

Pros:

  • Provides vet-quality, broad-spectrum protection against seven common worm species.
  • Flavorful, chewable tablets that are easy to administer by hand or mixed with food or treats.
  • Safe for puppies 12 weeks and older, with quick, effective results reported by many users.

Cons:

  • May require repeated dosing every 1-3 months depending on exposure and climate.
  • Some dogs might experience mild diarrhea post-treatment, which usually resolves quickly.
  • Must be administered carefully, especially when quartering larger pills for smaller puppies to avoid overdose.

Flea and Tick Prevention Chewables for Dogs (170 Treats)

dog flea tick chewables

If you’re looking for a natural, safe, and easy way to protect your dog from fleas and ticks, these YUMAS Flea and Tick Prevention Chewables are an excellent choice. They’re formulated with natural ingredients, suitable for all breeds and ages, including seniors. The tasty chicken-flavored soft chews are easy to give daily, turning treatment into a treat. Made in the USA in an FDA-registered facility, they’re safe and effective, with many owners reporting no fleas or ticks since starting. Each container provides 170 treats, making it a cost-effective way to keep your dog itch-free and protected, even in heavy tick environments.

Best For: dog owners seeking a natural, safe, and convenient flea and tick prevention solution suitable for all breeds and ages, including seniors.

Pros:

  • Made with natural ingredients, reducing concerns about chemical side effects.
  • Tasty chicken-flavored treats that dogs love, making daily administration easy.
  • Cost-effective with 170 treats per container, reducing the need for frequent repurchases.

Cons:

  • Effectiveness may vary; heavy infestations might require additional treatment methods.
  • Some owners report an unpleasant smell for humans, despite dogs enjoying the flavor.
  • Not a standalone solution in high-risk environments, potentially requiring supplementary measures.

DURVET 12-Pack Triple Wormer Tablets for Puppies and Small Dogs

puppy small dog tablets

For small dogs and puppies needing a convenient, no-prescription dewormer, DURVET 12-Pack Triple Wormer Tablets stands out as a top choice. These chewable tablets are easy to administer, often by hiding in food, and are highly rated with a 4.6-star average from thousands of reviews. They effectively treat and control tapeworms, roundworms, hookworms, and more, often eliminating worms overnight. Safe and affordable, they’re designed specifically for puppies and small dogs, making deworming simple and stress-free. Keep in mind, they don’t prevent heartworm, so a vet-prescribed product is still necessary for that.

Best For: small dogs and puppies seeking an easy, effective, and affordable dewormer without the need for a prescription.

Pros:

  • Highly effective against multiple intestinal parasites, often eliminating worms overnight
  • Tasty, small chewable tablets that are easy to administer and can be hidden in food
  • Safe, well-rated, and suitable for ongoing prevention with many users re-purchasing

Cons:

  • Does not prevent heartworm; requires additional medication prescribed by a veterinarian
  • Some pets may learn to avoid tablets, requiring hiding or crushing to administer effectively
  • Not suitable for larger dogs or those needing prescription-based parasite control

Sentinel Spectrum Chews for Dogs (6-Month Supply)

dog parasite prevention chews

Sentinel Spectrum Chews for Dogs (6-Month Supply) is an excellent choice for pet owners seeking all-encompassing parasite protection in a convenient, long-lasting form. These flavored chews protect against six parasite types, including heartworms, tapeworms, hookworms, roundworms, whipworms, and flea eggs. The active ingredient, lufenuron, prevents flea eggs from hatching, providing effective year-round control. Administer one chew monthly, either as a treat or mixed with food, making it easy to incorporate into your dog’s routine. Manufactured by Merck and available since August 2024, these chews are highly rated for their reliability, affordability, and simplicity.

Best For: dog owners seeking comprehensive, easy-to-administer, long-term parasite protection for dogs weighing 25.1-50 lbs.

Pros:

  • Provides protection against six different parasites, including worms and fleas
  • Flavored with beef and bacon, making administration appealing and easy
  • Convenient 6-month supply with monthly dosing for consistent protection

Cons:

  • Requires monthly administration, which may be challenging for some pet owners
  • Only suitable for dogs within the specified weight range (25.1-50 lbs)
  • Must be given with food or as a treat for optimal absorption

Flea and Tick Prevention Chewables for Dogs (180 Soft Chews)

dog flea tick chewables

Designed for dog owners seeking a natural and effective way to protect their pets from fleas and ticks, these chewables offer a convenient, tasty solution. With 180 soft chews in a delicious duck and pear flavor, they make daily prevention easy and enjoyable for your dog. Made with natural ingredients like Beta-Carotene, Perilla Seed Extract, and brewer’s yeast, they support long-term flea and tick defense while boosting your dog’s immune system with essential vitamins. Plus, they promote healthy skin, a shiny coat, and overall comfort. Safe, GMO-free, and free from artificial additives, these chews help keep your dog healthy and happy all year round.

Best For: dog owners seeking a natural, tasty, and effective solution for long-term flea and tick prevention that also supports overall health and coat wellness.

Pros:

  • Made with natural, high-quality ingredients free from artificial additives, GMOs, and common allergens.
  • Delicious duck and pear flavor that encourages regular consumption and supports digestion.
  • Provides comprehensive immune support with vitamins B2, B6, and C, while promoting healthy skin and a shiny coat.

Cons:

  • May require consistent daily administration for optimal protection.
  • Some dogs may be sensitive to certain natural ingredients; always check for allergies.
  • Not a replacement for veterinary-prescribed medications in areas with high flea or tick prevalence.

Trifexis Heartworm Prevention for Dogs 5-10 lbs. (6 Chewables)

dog heartworm prevention chewables

If you have a small dog weighing between 5 and 10 pounds, Trifexis Heartworm Prevention for Dogs is an excellent choice for all-inclusive parasite protection. It offers 5-in-1 coverage, including heartworm prevention, flea control, and treatment for roundworms, hookworms, and whipworms. The tasty beef-flavored chew makes administration easy, and it starts killing fleas within 30 minutes, reaching 100% adult flea kill in just four hours. With over 272 million doses distributed, it’s a trusted, long-lasting solution. Administer once a month, and continue for three months after mosquito exposure for complete heartworm prevention. Customers praise its effectiveness and ease of use.

Best For: small dogs weighing 5-10 pounds seeking comprehensive, easy-to-administer parasite protection including heartworm, fleas, and intestinal worms.

Pros:

  • Provides 5-in-1 protection including heartworm, fleas, roundworms, hookworms, and whipworms
  • Starts killing fleas within 30 minutes and achieves full adult flea kill in 4 hours
  • Tasty beef-flavored chewable tablets ensure easy administration

Cons:

  • Cost per pill may be higher compared to some alternative treatments
  • Requires monthly administration, which may be a challenge for some pet owners
  • Packaging contains 6 chewables, which may require additional purchase for long-term use

Flea and Tick Prevention Chewables for Dogs (120 Soft Treats)

dog flea tick chewables

Flea and tick prevention chewables for dogs, like the 120 soft treats made by Vet Treat, are an excellent choice for pet owners seeking a natural alternative to chemical pesticides. Made in the USA, these vet-recommended treats contain natural ingredients like flaxseed, neem, and coriander, with no chemicals or garlic. They support skin, coat, and immune health while repelling fleas and ticks effectively. Dogs enjoy the tasty chicken flavor, making daily administration easy. Many owners report reduced flea and tick issues within days, especially when combined with environmental control. These all-natural treats are suitable for all breeds and sizes, offering a safe, convenient solution for pest prevention.

Best For: pet owners seeking a natural, safe, and effective flea and tick prevention solution for dogs of all breeds and sizes.

Pros:

  • Made with natural ingredients like flaxseed, neem, and coriander, free from chemicals and garlic.
  • Tasty chicken flavor that dogs enjoy, making daily administration easy.
  • Supports skin, coat, and immune health while naturally repelling fleas and ticks.

Cons:

  • Effectiveness may vary; some dogs might experience only partial protection.
  • Requires consistent daily use and environmental control measures for best results.
  • May be less effective during heavy infestations compared to stronger chemical options.

PetArmor Plus Flea and Tick Prevention for Dogs

dog flea tick prevention

Looking for an effective flea and tick prevention solution for your large dog? PetArmor Plus Flea and Tick Prevention is a waterproof topical treatment suitable for dogs 12 weeks and older, weighing 45-88 lbs. It contains fipronil and (S)-methoprene, similar to FRONTLINE Plus, providing vet-quality protection at an affordable price. Each application kills fleas, ticks, eggs, larvae, and lice within 24 hours, offering 30 days of protection. Easy to apply—just part the fur and apply directly to the skin—this formula remains effective even after water exposure. A six-dose pack covers six months, making it a convenient, cost-effective choice for ongoing pest control.

Best For: large dogs weighing 45-88 lbs., 12 weeks and older, seeking a waterproof, monthly flea and tick prevention solution.

Pros:

  • Kills fleas, ticks, eggs, larvae, and lice within 24 hours, providing quick protection.
  • Waterproof formula remains effective after bathing or water exposure.
  • Easy to apply by parting fur and applying directly to the skin, with a six-month supply for convenience.

Cons:

  • Does not prevent fleas or ticks from hopping onto pets or humans; environmental control needed.
  • May have limited effectiveness against some ticks, especially in high-exposure areas.
  • Requires proper environmental management (yard and home treatments) to fully eliminate infestations.

IVERHART Plus Chewables for Dogs (51-100 lbs)

dog multivitamin chewables large

For dogs weighing between 51 and 100 pounds, IVERHART Plus Chewables stand out as a reliable choice for heartworm prevention. These flavored pork liver chewables are easy to administer once a month, offering effective protection against heartworm larvae. IVERHART Plus is safe for pregnant or breeding bitches, stud dogs, and puppies over six weeks old, thanks to its wide safety margin. It works quickly, eliminating existing heartworm larvae within 30 days and preventing their development into adult worms. Manufactured by Virbac, these chewables provide a convenient and trusted solution to keep your dog healthy and protected year-round.

Best For: dogs weighing 51-100 pounds seeking a safe, effective, and convenient monthly heartworm prevention solution.

Pros:

  • Flavored pork liver chewables are easy to administer and well-accepted by dogs.
  • Provides rapid elimination of heartworm larvae within 30 days, preventing adult worm development.
  • Safe for pregnant, breeding, and young puppies over six weeks old, with a wide safety margin.

Cons:

  • Must be given monthly, requiring owners to remember administration schedule.
  • Does not treat existing adult heartworms, only prevents new infections.
  • May not be suitable for dogs outside the specified weight range without proper dosing adjustments.

Factors to Consider When Choosing Heartworm Prevention Chews

choosing safe effective chews

When choosing heartworm prevention chews, I consider several key factors to guarantee my dog’s safety and convenience. I look at the active ingredients to make sure they’re safe and effective, and I check if the size matches my dog’s weight. I also consider how easy it is to give, how often I need to administer it, and whether it offers protection against other parasites.

Active Ingredient Safety

Ever wonder if the active ingredients in heartworm prevention chews are safe for your dog? It’s essential to check that these ingredients are approved by the FDA and have a solid safety record. Some common ingredients, like ivermectin or milbemycin oxime, can cause side effects or adverse reactions in certain dogs, so knowing their safety profile helps you make an informed choice. Make certain the ingredients are safe for dogs at all life stages, including pregnant or breeding dogs, to avoid any risks. Also, consider the dosage margin and safety testing data—this shows how tolerant your dog might be to accidental overdoses. Finally, always talk to your veterinarian to confirm the active ingredients suit your dog’s specific health needs and medications.

Dog Size Compatibility

Choosing the right heartworm prevention chew starts with making sure it’s formulated for your dog’s specific size. It’s vital to check the product label to confirm it matches your dog’s weight range, such as up to 25 pounds or over 50 pounds, to avoid under- or over-dosing. Some formulations are designed for small, medium, or large dogs, with different active ingredient concentrations tailored for each size. Using a product not suited for your dog’s size can reduce its effectiveness or cause adverse effects. Always verify the weight range listed on the packaging before giving a chew. Proper size compatibility guarantees your dog gets the right dose for maximum protection and safety, making it an essential factor in choosing the best heartworm prevention treat.

Administration Ease

Ease of administration plays a essential role in guaranteeing your dog consistently receives heartworm prevention. Chewable heartworm preventives are typically designed to be palatable, making them easier for dogs to accept than pills or injections. Many come in flavors like beef, chicken, or pork liver, encouraging dogs to chew thoroughly and reducing resistance during administration. To guarantee effectiveness, it’s important to give the entire dose at once—either directly by hand or mixed with food. Some chews have markings or break lines to help split doses for smaller dogs or those that swallow treats whole. Clear instructions and sticking to a consistent schedule make administering these chews straightforward, minimizing missed doses and helping maintain continuous protection for your dog’s health.

Frequency of Dosing

The frequency at which you administer heartworm prevention chews depends on several factors, including your dog’s risk level and local mosquito activity. Most chews require monthly dosing to stay effective against heartworm larvae, but some products are designed for three or six-month schedules, reducing how often you need to give them. Consistency is key—missing doses can create gaps in protection and increase infection risk. The best schedule depends on your area’s heartworm prevalence and your veterinarian’s advice. In regions with year-round mosquito activity, more frequent dosing ensures continuous coverage. Ultimately, sticking to the recommended schedule and following your veterinarian’s guidance will help keep your dog safe and healthy. Proper timing is essential for effective prevention.

Broader Parasite Coverage

When selecting heartworm prevention chews, it’s important to contemplate their ability to protect against multiple parasites beyond just heartworms. Many multi-spectrum chews include ingredients like praziquantel, pyrantel, and milbemycin oxime, which target intestinal worms such as roundworms, hookworms, whipworms, and tapeworms. This extensive coverage reduces the need for separate deworming treatments and minimizes parasite transmission from the environment or other animals. Some formulations also combine flea and tick prevention, offering year-round protection in a single treatment. Choosing a product with thorough parasite coverage simplifies your pet’s health routine, enhances overall protection, and boosts compliance. It’s a practical way to keep your dog safe from a variety of internal and external parasites.

Price and Value

Choosing the right heartworm prevention chews involves more than just looking at the price tag; it’s about balancing cost with value. Prices can range from $15 to $30 a month, but the key is comparing the cost per dose. Buying in bulk or subscribing to auto-shipment often saves you $5 to $10 per cycle, making it more affordable long-term. Some brands have higher upfront costs but offer longer protection or broader parasite coverage, which can be more cost-effective over time. It’s also important to contemplate other factors like effectiveness, palatability, and additional benefits. Ultimately, the best value comes from choosing a product that provides reliable protection at a fair price, ensuring your dog stays healthy without overspending.

Long-Term Effectiveness

Long-term effectiveness hinges on guaranteeing that the active ingredients in heartworm prevention chews stay at consistent, protective levels in your dog’s bloodstream. Monthly dosing is vital to maintain continuous protection, preventing any gaps that could allow heartworm larvae to grow into adult worms. Some formulations feature sustained-release properties, offering longer-lasting protection beyond 30 days, which can be convenient for busy schedules. Proper adherence to the dosing schedule, including redosing if a dose is missed, is essential for effectiveness. Regular veterinary visits and testing are also recommended to confirm that the prevention remains effective over time. By choosing a product that supports consistent blood levels and sticking to the schedule, you help guarantee your dog stays protected year-round.

Product Approval Status

Ensuring that the heartworm prevention chew is approved by reputable authorities is essential for reliable protection. I always check if the product is approved by the FDA or an equivalent regulatory agency, as this confirms safety and efficacy. It’s important to verify whether the product has received official approval or certification from recognized veterinary pharmacology bodies. I look for documentation or labels indicating the product has undergone clinical trials and has veterinary approval. Confirming that the claims made by the product are backed by scientific evidence and regulatory processes gives me confidence in its effectiveness. I avoid unapproved or homemade remedies, since they lack official approval and may not reliably protect my dog from heartworm disease. Approval status is a crucial factor in making an informed choice.

Frequently Asked Questions

Are Heartworm Prevention Chews Suitable for Puppies?

You’re wondering if heartworm prevention chews are suitable for puppies. I believe they can be, but it’s essential to check the age and weight requirements on the package. I always consult my vet before starting any medication for my puppy, as they can recommend the right dosage and brand. Proper prevention is vital, and these chews are a convenient way to protect your puppy from heartworms effectively.

How Do I Store These Chews to Maintain Effectiveness?

Storing these chews properly is like safeguarding a treasure chest because their effectiveness depends on it. I keep mine in a cool, dry place away from direct sunlight, ensuring they don’t get exposed to heat or moisture that could weaken their power. I also make sure the container is tightly sealed. Proper storage keeps the active ingredients potent, so my pup stays protected and healthy every time.

Can I Give Multiple Types of Prevention Chews Simultaneously?

You might wonder if you can give your dog multiple prevention chews at once. I wouldn’t recommend it because overlapping medications can cause adverse reactions or reduce effectiveness. Always follow your vet’s advice and stick to one product at a time. Combining different preventatives without guidance could risk your dog’s health. If you’re considering multiple options, talk to your veterinarian first for a safe, tailored approach.

What Are the Signs of Adverse Reactions to These Chews?

Oh, the irony is real—thinking your dog might be allergic to a treat you’ve carefully chosen! Signs of adverse reactions include itching, swelling, vomiting, diarrhea, or difficulty breathing. If any of these pop up, don’t wait around; I immediately contact my vet. It’s better to be cautious than to risk a serious health issue. Always monitor your pup closely after giving any new medication or treat.

Are There Natural or Organic Heartworm Prevention Options Available?

You’re wondering if natural or organic heartworm prevention options exist. I’ve researched this and found some alternative methods, like using certain herbal supplements and maintaining a healthy, clean environment to reduce mosquito exposure. However, I always recommend consulting your veterinarian before trying natural options, as they can provide guidance tailored to your dog’s specific needs. Remember, prevention is key, and professional advice guarantees your furry friend stays safe and healthy.

Conclusion

Choosing the right heartworm prevention chews is like finding the perfect shield for your loyal guardian. Each option acts as a sturdy armor, protecting your dog from unseen threats. Remember, a strong shield keeps the battle at bay, ensuring your furry friend stays healthy and happy. So, pick the one that fits best—because a well-armed dog is a happy companion in life’s great adventure.

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